determination of levonorgestrel and ethinyl estradiol in pharmaceutical formulations by h-point standard addi-tion method in nonaqueous solvent using simultaneous addition of both analytes
نویسندگان
چکیده
h-point standard addition method (hpsam) with simultaneous addition of both analytes in nonaqueous solution was applied for determination of levonorgestrel (lev) and ethinyl estradiol (ee) in ld and hd tablets. the results showed that, simultaneous determination could be performed with the ratio 1 to 5 of lev-ee. the lod for lev and ee were obtained 5.1×10 -7 and 9.6×10 -7 m, respectively, and the corresponding values of %rsd (n=4) for lev and ee were 1.96 and 2.69, respectively. underworking conditions, the proposed method was successfully applied for simultaneous determination of lev and ee in several synthetic mixtures and ld and hd tablets.
منابع مشابه
Simultaneous Spectrophotometric Determination of Vanadium(V) and Iron(III) in Micellar Medium by H-Point Standard Addition Method
H-Point Standard Addition Method (HPSAM) was applied for the simultaneous determination of V(V) and Fe(III). The method is based on the complex formation of V(V) and Fe(III) with chromazurol S (CAS) in acidic media and in the presence of cetyltrimethylammonium bromide (CTAB) as a micellizing agent. Acidic media and the presence of a micellar system improve selectivity and sensitivity. Fe (I...
متن کاملsimultaneous spectrophotometric determination of amlodipine and atorvastatin in commercial tablet by h-point standard addition method
متن کامل
simultaneous spectrophotometric determination of vanadium(v) and iron(iii) in micellar medium by h-point standard addition method
h-point standard addition method (hpsam) was applied for the simultaneous determination of v(v) and fe(iii). the method is based on the complex formation of v(v) and fe(iii) with chromazurol s (cas) in acidic media and in the presence of cetyltrimethylammonium bromide (ctab) as a micellizing agent. acidic media and the presence of a micellar system improve selectivity and sensitivity. fe (iii) ...
متن کاملLiquid Chromatographic And Spectrophotometric Determination Of Ethinyl Estradiol And Levonorgestrel In Pharmaceutical Preparations
The present work describes a new HPLC method and a new spectrophotometric method for the simultaneous determination of ethinyl estradiol (EE) and levonorgestrel (LNG) in their binary combination. In LC method, Nucleosil C8 column with a mobile phase composed of acetonitrile-water (90:10, v/v) with UV detection at 225 nm were used for the analysis of ethinyl estradiol-levonorgestrel combination....
متن کاملSimultaneous kinetic determination of beryllium and aluminium by spectrophotometric H-point standard addition method.
The H-point standard addition method (HPSAM), based on spectrophotometric measurements for simultaneous determination of beryllium and aluminium, is described. This method is based on the difference between their rates of reactions with Chrome Azurol S (CAS) in cetyltrimethylammonium bromide (CTAB) micellar media. The results showed that beryllium and aluminium could be determined simultaneousl...
متن کاملSimultaneous kinetic spectrophotometric determination of citric and ascorbic acid by H-point standard addition method
The H-point standard addition method was applied to kinetic data for simultaneous determination of citric and ascorbic acid or selective determination of ascorbic acid in presence of citric acid. The method is based on the difference in the rate of reaction of citric and ascorbic acid with copper(II)-ammonia complex. The linear dynamic ranges for the two analytes of citric and ascorbic acid are...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of reports in pharmaceutical sciencesجلد ۱، شماره ۱، صفحات ۷-۱۸
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023